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Coronaviruses: An Overview of Their Replication and Pathogenesis

Published time: 01.01.2016

Authors: Anthony R. Fehr, Stanley Perlman

Keywords: Nidovirales, Coronavirus, positive-sense RNA viruses, SARS-CoV, MERS-CoV


Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We will also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).

10.Coronaviruses; An Overview of Their Replication and Pathogenesis.



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