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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Published time: 26 March 2020

Authors: Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Andrew Chak-Yiu Lee, Wan-Mui Chan, Zhimeng Fan, Hoi-Wah Tsoi, Lei Wen, Ronghui Liang, Jianli Cao, Yanxia Chen, Kaiming Tang, Cuiting Luo, Jian-Piao Cai, Kin-Hang Kok, Hin Chu, Kwok-Hung Chan, Siddharth Sridhar, Zhiwei Chen, Honglin Chen, Kelvin Kai-Wang To

Keywords: coronavirus, COVID-19, SARS-CoV-2, animal, transmission


Molecular docking on the binding between angiotensin-converting enzyme 2 (ACE2) of common laboratory mammals and the receptor-binding domain of the surface spike protein of SARS-CoV-2 suggested that a golden Syrian hamster is an option. Virus challenge, contact transmission, and passive immunoprophylaxis were performed. Serial organ tissues and blood were harvested for histopathology, viral load and titre, chemokine/cytokine assay, and neutralising antibody titre.

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model; implications for disease pathogenesis and transmissibility



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