Articles Public Health Articles

Detection of Serum IgM and IgG for COVID-19 Diagnosis

Published time: 25 March 2020

Authors: Ling Zhong, Junlan Chuan, Bo Gong, Ping Shuai, Yu Zhou, Yi Zhang, Zhilin Jiang, Dingding Zhang, Xiaoqi Liu, Shi Ma, Yi Huang, He Lin, Qingwei Wang, Lulin Huang, Dan Jiang, Fang Hao, Juan Tang, Chunqi Zheng, Hua Yu, Zhibin Wang, Qi Jiang, Tao Zeng, Mei Luo, Fanwei Zeng, Fanxin Zeng, Jianghai Liu, Junxi Tian, Yu Xu, Tengxiang Long, Kaiju Xu, Xingxiang Yang, Yuping Liu, Yi Shi, Li Jiang, Zhenglin Yang

Keywords: Covid-19, Coronavirus, Diagnostic, Infection


Infection with the novel coronavirus (SARS-CoV-2, which is the virus responsible for the coronavirus disease 2019 (COVID-19)) was first reported in Wuhan, China on December 31, 2019. The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7, 2020 (Holshue et al., 2020). Currently, the real-time RT-PCR assay is the gold-standard method to diagnose SARS-CoV-2. However, false-negative cases have been reported due to problems with sample collection and transportation, RNA extraction, enzyme inhibitors, and the RT-PCR method (Yang et al., 2020; Lu et al., 2020). By contrast, conventional serological assays, such as the enzyme-linked immunoassay (ELISA) for specific IgM and IgG antibodies, have a high-throughput advantage, and they avoid false-negative cases that occur with the RTPCR method (Xiao et al., 2020)

Detection of serum IgM and IgG for COVID-19 diagnosis



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