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Enteric Involvement in Hospitalised Patients with COVID-19 Outside Wuhan

Published time: 15 April 2020

Authors: Yunle Wan, Jie Li, Lihan Shen, Yifeng Zou, Linlin Hou, Lixin Zhu, Howard S Faden, Zhipeng Tang, Mang Shi, Na Jiao, Yichen Li, Sijing Cheng, Yibo Huang, Dingfeng Wu, Zhifeng Xu, Linnuo Pan, Jun Zhu, Guangjun Yan, Ruixin Zhu, Ping Lan

Keywords: Covid-19, gastrointestial symptoms, severe acute syndrome


Early studies, of coronavirus disease 2019 (COVID-19) reported that the proportion of patients presenting with gastrointestinal symptoms was low. However, evidence for enteric involvement is emerging. Recently, a multicentre study in Hubei province (China) indicated that gastrointestinal symptoms were common in patients with COVID-19. We examined the intestinal symptoms of patients with COVID-19 from multiple medical centres located in and outside of Hubei province.

We retrospectively analysed data from 232 patients who were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA admitted to 14 hospitals (two hospitals in Guangdong province, two in Hubei province, and ten in Jiangxi province) between Jan 19, 2020, and March 6, 2020. Most patients were admitted because of fever, cough, dyspnoea, and chest CT findings consistent with COVID-19 pneumonia. Diagnosis of COVID-19 was based on positive SARS-CoV-2 RNA tests. Two patients with pre-existing digestive diseases were excluded from our analysis. The analysis was approved by the institutional review boards of Sun Yat-sen University and the participating hospitals.

Enteric involvement in hospitalised patients with COVID-19 outside Wuhan



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