Published time: 07 May 2020
Authors: Thomas J. Hwang, Adrienne G. Randolph, Florence T. Bourgeois
Keywords: Covid-19, Children, clinical trials, case study
Clinical trials of several novels and repurposed therapies for coronavirus disease 2019 (COVID-19) are being rapidly designed or already enrolling patients. However, few trials are currently open to enrolling children. Between February 1 and April 11, 2020, there were 275 COVID-19 interventional clinical trials registered on ClinicalTrials.gov, of which only 30 were open to any patients younger than 18 years (Figure). Global large-scale trials by the National Institutes of Health (NIH) and the World Health Organization that plan to study multiple treatment options simultaneously (ie, the Adaptive COVID-19 Treatment Trial1 and SOLIDARITY Trial,2 respectively) plan to enroll only adults according to study protocols as of April 15, 2020.
Inclusion of Children in Clinical Trials of Treatments for Coronavirus Disease 2019 (COVID-19)