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Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study with Implications for the Pathogenesis of COVID-19

Published time: 09 April 2020

Authors: Hin Chu,  Jasper Fuk-Woo Chan,  Yixin Wang,  Terrence Tsz-Tai Yuen,  Yue Chai, Yuxin Hou,  Huiping Shuai,  Dong Yang,  Binjie Hu,  Xiner Huang,  Xi Zhang, Jian-Piao Cai,  Jie Zhou,  Shuofeng Yuan,  Kin-Hang Kok,  Kelvin Kai-Wang To, Ivy Hau-Yee Chan,  Anna Jinxia Zhang,  Ko-Yung Sit,  Wing-Kuk Au, Kwok-Yung Yuen

 Keywords: coronavirus, COVID-19, ex vivo, interferon, SARS-CoV-2


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that has resulted in nearly 1,000,000 laboratory-confirmed cases including over 50,000 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, SARS-CoV-2 appears to be highly efficient in person-to-person transmission and frequently cause asymptomatic infections. However, the underlying mechanism that confers these viral characteristics on high transmissibility and asymptomatic infection remain incompletely understood.

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs; an ex vivo study with implications for the pathogenesis of COVID-19



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