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Early Virus Clearance and Delayed Antibody Response in a Case of COVID-19 with a History of Co-Infection with HIV-1 and HCV

Published time: 09 April 2020

Authors: Juanjuan Zhao,  Xuejiao Liao,  Haiyan Wang,  Lanlan Wei,  Mingzhao Xing,  Lei Liu, Zheng Zhang

 Keywords: SARS-CoV-2, COVID-19, HIV-1, HCV, Antibody


The effect of host immune status on SARS-CoV-2 infection remains unknown. Here, we report the first case of COVID-19 with HIV-1 and HCV co-infection, who showed a persistently negative SARS-CoV-2 RNA test, but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on the early SARS-CoV-2 clearance.

Early virus clearance and delayed antibody response in a case of COVID-19 with a history of co-infection with HIV-1 and HCV



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