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Potential Role of Memantine in the Prevention and Treatment of COVID-19: Its Antagonism of Nicotinic Acetylcholine Receptors (nAChR) and Beyond

Published time: 18 June 2020

Authors: Senad Hasanagic, Fadila Serdarevic

Keywords: Angiotensin, respiratory, pathogenicity, nervous system.


Recently, Leung et al. proposed that α7-nAChR antagonists might decrease angiotensin-converting enzyme (ACE2) receptors expression in respiratory epithelium and, hence, prevent SARS-CoV-2 invasion of pulmonary epithelial cells (1). Let us further theoretically evaluate this assertion and contribute to the quest for potential medications that might reduce virulence and pathogenicity of COVID-19. Smoking may be associated with progression and negative outcome of coronavirus disease 2019 (COVID-19) (1). The receptor binding domain of S protein (spike) on the surface of SARS CoV-2 interacts with angiotensin-converting enzyme (ACE2) receptor- which is an entry point of virus into host respiratory cells .

Potential role of memantine in the prevention and treatment of COVID-19 its antagonism of nicotinic acetylcholine receptors (nAChR) and beyond



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