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Treatments For People With Early COVID-19 Infection Is An Urgent Research Focus

Effective, early interventions would benefit individual patients and healthcare system.


COVID-19 treatments for people with early infection are needed urgently, according to a JAMA Viewpoint article by National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony S. Fauci, M.D., and colleagues. Treating people early in the course of infection with SARS-CoV-2, the virus that causes COVID-19, would speed their recovery, reduce the likelihood that they develop severe outcomes and reduce demand on the healthcare system, they write.

Despite experiencing only mild symptoms early in infection, many COVID-19 patients progress to severe disease that leads to hospitalization. Some also will experience lengthy recoveries and develop long-lasting fatigue, mental impairment and problems with heart and lung function.

While several treatments such as remdesivir and dexamethasone are either available or in development for severe COVID-19, interventions that can be administered early during the course of infection to prevent disease progression and longer-term complications are urgently needed.

Studies are underway to assess whether existing antivirals can be repurposed for early treatment.  Scientists also are exploring the effectiveness of early treatment with therapies that specifically target SARS-CoV-2, such as convalescent plasma and monoclonal antibodies. Investigators also are exploring strategies to deliver therapies by alternative routes than by intravenous infusion, such as by inhalation or intramuscular injection.

Continued research is needed to refine current treatment candidates and develop new drugs, and  treatments will need to be administered easily and made available widely at low cost, according to the authors.

The article also highlights the need to design novel antiviral treatment approaches akin to successful efforts for hepatitis C virus and HIV. Such approaches could be helpful against future emergent viruses as well.

The article says robust support from the medical community and public is needed to ensure the success of these critical areas of research. Those interested in learning more about an ongoing NIAID-sponsored trial (ACTIV-2) evaluating therapies for people who were recently diagnosed with COVID-19 but are not hospitalized can visit: is external) or go to and search NCT04518410.


P Kim, et al. Therapy for Early COVID-19 – A Critical Need. Journal of the American Medical Association DOI: DOI:10.1001/jama.2020.22813 (2020).


NIAID Director Anthony S. Fauci, M.D., is available to comment on this article.

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit


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